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KMID : 1098420010090020116
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Korean Journal of Medicinal Crop Science
2001 Volume.9 No. 2 p.116 ~ p.123
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Study on the biological activity of Artemisia iwayomogi KITAMURA
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김범석/Kim, Bum Suk
류지성/곽준수/송영은/정주리/김대향/임채웅/Ryu, Ji Sung/Kwak, Joon Soo/Song, Young Eun/Chung, Ju Ri/Kim, Dae Hyang/Rim, Chai Woong
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Abstract
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This study was carried out to investigate antioxidative, antimicrobial activity and the effect on hepatotoxicity in various extracts of Artemisia iwayomogi. The herb has been used widely for jaundice, hepatitis and liver cirrhosis in chinese medicine. Solid yield by various extraction solvents, 18.1%, was the highest in water extract. To find antioxidative activity in Artemisia iwayomogi was estimated radical scavenging effect by DPPH method in various extracts and change of the POV(peroxide value) of various extracts added in soybean oil during 20 days at $60^{\circ}C$ 수식 이미지. Radical scavenging effect by DPPH method was the most effective in methanol extract. Added 1,000ppm water extract and methanol extract in soybean oil, the POV of them, 46.8(meq/kg) and 50.8(meq/kg) were lower than that of control, 79.1(meq/kg), during 20 days storage. After antimicrobial activity of various extracts of Artemisia iwayomogi on bacteria was carried out by paper disc method, it found that the ethanol extract was the strongest activity on Vibrio parahaemolyticus. In vivo experiment was to investigate the effect of Artemisia iwayomogi water extract(AIWE) on hepatotoxicity by carbon tetrachloride$(CCl_4)$ 수식 이미지 in rats. The experiment groups were divided into five groups for recovery(for 3 days) and three groups for protection(for 10 days) in rat liver. The weights and morphological changes of liver and the body weight were examined in each groups. Compared with $CCl_4$ 수식 이미지 treatment groups$(CCl_4\;only)$ 수식 이미지, liver and liver/body(%) weights of AIWE pretreatment groups for 3 days and AIWE posttreatment groups for 10 days were declined. In macrography, fibrious exudates and swelling of liver were decreased in AIWE treatment groups. Accumulation of lipid droplets and necrosis of hepatocytes were also decreased in AIWE treatment groups in microscopically. In these results, AIWE seems to enhance hepato-protective and recoverable effect on $CCl_4$ 수식 이미지 induced hepatotoxicity in rats.
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KEYWORD
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antioxidative activity, antimicrobial activity, hepatotoxicity, Artemisia iwayomogi
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